Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.

@article{Tyler2011FocusOT,
  title={Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.},
  author={Jessica S. Tyler and Moritz Treeck and John C Boothroyd},
  journal={Trends in parasitology},
  year={2011},
  volume={27 9},
  pages={
          410-20
        }
}
Apicomplexan parasites exhibit an unusual mechanism of host cell penetration. A central player in this process is the protein apical membrane antigen 1 (AMA1). Although essential for invasion, the precise functional roles AMA1 plays have been unclear. Several recent studies have provided important functional insight into its role within the multiprotein complex that comprises the moving junction (MJ). Initially formed at the apical tip of the invading parasite, the MJ represents a ring-like… CONTINUE READING
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