Focus on molecules: MERTK.

  title={Focus on molecules: MERTK.},
  author={David J Strick and Douglas Vollrath},
  journal={Experimental eye research},
  volume={91 6},
MERTK (UniProt accession Q12866, EC is a single pass transmembrane receptor that belongs to the TAM (Tyro3, Axl and Mertk) family of receptor tyrosine kinases. MERTK is highly expressed in monocytes/macrophages, testis and epithelial cells including the retinal pigment epithelium (RPE) (Fig. 1A). The human MERTK gene is located on chromosome 2 (2q14.1) and consists of 19 exons that encode a 999 amino acid protein with a predicted molecular weight of 110 kDa. The actual molecular… CONTINUE READING


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