Focus on cannabinoids and synthetic cannabinoids

@article{LeBoisselier2017FocusOC,
  title={Focus on cannabinoids and synthetic cannabinoids},
  author={Reynald Le Boisselier and Joachim Alexandre and V{\'e}ronique Lelong-Boulouard and Dani{\`e}le Debruyne},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2017},
  volume={101}
}
The recent emergence of a multitude of synthetic cannabinoids (SCs) has generated a wealth of new information, suggesting the usefulness of state‐of‐the‐art on lato sensu cannabinoids. By modulating a plurality of neurotransmission pathways, the endocannabinoid system is involved in many physiological processes that are increasingly explored. SCs desired and adverse effects are considered to be more intense than those observed with cannabis smoking, which is partly explained by the full agonist… 
Cannabinoids as anticancer therapeutic agents
TLDR
This review will comprehensively summarize the activity of all groups of cannabinoids on various cancers and propose several potential mechanisms of action of cannabinoid on cancer cells.
Synthetic cannabinoids: characteristics, use and clinical implications
TLDR
The most important characteristics of these substances, the consequences of their consumption and the clinical implications that derive from it are reviewed.
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
TLDR
Synthetic cannabinoids are one of the most promising classes of drugs in pain medicine, and preclinical research should focus on identifying new and improved alternatives for a better clinical and pre clinical outcome.
Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
TLDR
It is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, with astonishing affinity and selectivity.
Uses, Effects and Toxicity of Synthetic Cannabinoids from the Perspective of People with Lived Experiences
TLDR
The effects of SCs and the underlying motivations of use among participants with lived experiences are explored and the lived experiences of people who used novel psychoactive substances (NPSs) are studied to guide future research in the field.
Synthetic Cannabinoids and Cardiac Arrhythmia Risk: Review of the Literature
TLDR
Understanding the exact association and possible mechanisms of the SCB related arrhythmia remains unknown may help to identify high risk patients at an early stage and to develop treatment modalities to prevent or reverse the arrhythmmic effects of SCBs.
Pharmacodynamics of cannabinoids
  • A. Šulcová
  • Biology
    Archives of Pharmacy and Pharmaceutical Sciences
  • 2019
TLDR
The determination of THC structure by means of nuclear magnetic resonance imaging increased sharply the number of professional reports dealing with the studies of THC pharmacodynamic mechanisms of action, and it has been possible to verify THC binding sites in the vertebrate organisms including humans named “cannabinoid receptors”.
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites
TLDR
Current SC prevalence is reviewed, the necessity for SC metabolism investigation is established and the advantages and disadvantages of multiple metabolic approaches are compared, and a practical strategy to select optimal urinary marker metabolites for SCs is devised.
Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective
TLDR
This review will focus on neuroimmunological mechanisms for cannabinoid effects and their possible use as protective and therapeutic agents in the ear and auditory system, especially in tinnitus.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 86 REFERENCES
Emerging drugs of abuse: current perspectives on synthetic cannabinoids
TLDR
For the past 5 years, an ever increasing number of compounds, representative of different chemical classes, have been promoted and now represent a large assortment of new popular drugs of abuse, which are difficult to properly identify.
Synthetic cannabinoids 2015: An update for pediatricians in clinical practice.
TLDR
Pediatricians are urged to familiarize themselves with these drugs and the typical presentations of patients who use them and the diagnosis remains primarily clinical with toxicological confirmation difficult due to manufacturers constantly developing new analogues to avoid detection.
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities
  • R. Pertwee
  • Biology, Medicine
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2012
TLDR
This review mentions several possible additional therapeutic targets for cannabinoid receptor agonists and describes potential strategies for improving the efficacy and/or benefit-to-risk ratio of these agonists in the clinic.
Cannabidiol, neuroprotection and neuropsychiatric disorders.
A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids.
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
TLDR
It is suggested that inhibition of anandamide deactivation may contribute to the antipsychotic effects of cannabidiol potentially representing a completely new mechanism in the treatment of schizophrenia.
Medicinal chemistry of cannabinoids
TLDR
This review provides an overview of cannabinergic agents used in drug research and those being explored clinically, and the enzymes involved in their biosynthesis and biotransformation.
Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives
TLDR
Preclinical data is reviewed showing how the endocannabinoid and nicotinic cholinergic systems interact bidirectionally at the level of the brain reward pathways, and how this interaction plays a key role in modulating nicotine and cannabinoid intake and dependence.
A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment
TLDR
To identify systematically the scientific reports of adverse events associated with the consumption of SCs in the medical literature and poison centre data, this work searched online databases and manually searched reference lists up to December 2014 to identify eligible studies.
...
1
2
3
4
5
...