Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension

@inproceedings{Wright2012FocusOB,
  title={Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension},
  author={John Wesley Wright and Shigehiko Mizutani and Joseph W. Harding},
  booktitle={International journal of hypertension},
  year={2012}
}
The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins) independent of the peripheral system significantly expanded the possible physiological and pharmacological functions of this system. This paper first describes the enzymatic pathways resulting in… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 145 REFERENCES

Novel angiotensin peptides.

  • Cellular and molecular life sciences : CMLS
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

International union of pharmacology. XXIII. The angiotensin II receptors

M. De Gasparo, K. J. Catt, T. Inagami, J. W. Wright, T. Unger
  • Pharmacological Reviews, vol. 52, no. 3, pp. 415–472, 2000.
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Angiotensin-Converting Enzyme 2: The First Decade

  • International journal of hypertension
  • 2012
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan.

  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2008
VIEW 12 EXCERPTS

Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2003
VIEW 3 EXCERPTS

Effects of human placental aminopeptidases in spontaneously hypertensive rats

S. Mizutani, M. Furuhashi, +3 authors Y. Tomoda
  • Medicinal Science Research, vol. 15, no. 1, pp. 1203–1204, 1987.
  • 1987
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL