Focus: Chagas disease

@article{Morel2003FocusCD,
  title={Focus: Chagas disease},
  author={C. Morel and J. Lazdins},
  journal={Nature Reviews Microbiology},
  year={2003},
  volume={1},
  pages={14-15}
}
The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
TLDR
Diverse molecular mechanisms underlying thymic abnormalities occurring during T. cruzi infection and their link with CCC may contribute to the design of innovative strategies to control Chagas disease pathology. Expand
T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment
TLDR
It is suggested that at 48 months after benznidazole treatment, the disease can worsen or progress to the cardiac form and patients with the indeterminate form of Chagas disease show a more balanced ratio of proinflammatory and anti-inflammatory cytokines. Expand
Therapeutical effects of vaccine from Trypanosoma cruzi amastigote surface protein 2 by simultaneous inoculation with live parasites
TLDR
The results highlighted an increased oxidative stress, MMP‐2 activity and inflammatory host response promoted by AdASP‐2 against T cruzi infection. Expand
Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM)
BackgroundTrypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termedExpand
Does Triatoma brasiliensis occupy the same environmental niche space as Triatoma melanica?
TLDR
The ecological niche models show that the environmental spaces currently occupied by T. brasiliensis and T. melanica are similar although not equivalent, and associated with the caatinga ecosystem, and suggest that the separation of the two species should be attributed to a factor that does not include the current environmental conditions. Expand
Trypanosomal Trans-sialidases: Valuable Synthetic Tools and Targets for Medicinal Chemistry.
In contrast to the general hydrolases, trans-sialidase from Trypanosoma cruzi (TcTS) shows excellent regio- and stereoselectivity as well as high yields in transfer reactions. Discussed are theExpand
Vitamin A supplements, routine immunization, and the subsequent risk of Plasmodium infection among children under 5 years in sub-Saharan Africa
TLDR
National survey data from children aged 6–59 months in four sub-Saharan African countries over an 18-month time period was analyzed to determine the risk of parasitemia and Plasmodium falciparum HRP-2-related antigenemia following vitamin A supplementation and standard vaccination. Expand
Aptamer Based, Non-PCR, Non-Serological Detection of Chagas Disease Biomarkers in Trypanosoma cruzi Infected Mice
TLDR
This study has demonstrated that, using a SELEx based approach, parasite specific ligands called aptamers, can be used to detect TESA in the plasma of T. cruzi infected mice and shows that Apt-L44 could be used in a qualitative ELA assay to detect biomarkers of Chagas disease. Expand
Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease
TLDR
It is shown that sphingosine-1-phosphate (S1P), a potent mediator of T cell chemotaxis, plays a role in the exit of immature double-negative thymocytes in experimental Chagas disease. Expand
A Parent-of-Origin Effect Determines the Susceptibility of a Non-Informative F1 Population to Trypanosoma cruzi Infection In Vivo
TLDR
The genetic approach of using the F1 population suggests that genes contained in the murine chromosome X contribute to the natural resistance against T. cruzi infection. Expand
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References

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The autoimmunity hypothesis has remained controversial because of experimental pitfalls, incomplete or inadequate controls, difficulties in reproducing some key results, and a lack of persuasive evidence that the cross-reactive antibodies or lymphocytes can truly effect the multifaceted pathological features of Chagas disease. Expand
A Trypanosoma cruzi Small Surface Molecule Provides the First Immunological Evidence that Chagas' Disease Is Due to a Single Parasite Lineage
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