Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region.

@article{Guyton1990FocalTO,
  title={Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region.},
  author={John R. Guyton and Brian L Black and Charles L. Seidel},
  journal={The American journal of pathology},
  year={1990},
  volume={137 2},
  pages={425-34}
}
Cell necrosis and reactive cellular processes in and near the atherosclerotic core region might result from short-range interactions with toxic lipids. To model these interactions in cell culture, focal crystalline deposits of cholestane-3 beta,5 alpha,6 beta-triol, 25-OH cholesterol, and cholesterol were overlaid by a collagen gel, on which canine aortic smooth muscle cells were seeded. Oxysterols, but not cholesterol, caused focally decreased plating efficiency and cell death, leading to the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…