Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study

@article{Schuster2013FocalTO,
  title={Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study},
  author={Christina Schuster and Elisabeth Kasper and Judith Machts and Daniel Bittner and J. Kaufmann and Reiner Benecke and Stefan Teipel and Stefan Vielhaber and Johannes Prudlo},
  journal={Journal of Neurology},
  year={2013},
  volume={260},
  pages={2856-2864}
}
Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of upper (UMN) and lower motor neurons (LMN).We aimed to relate clinical variables to cortical thinning of the primary motor cortex (PMC). The PMC was defined as the region of interest in high-resolution structural MRI scans. We related vertex-wise measures of cortical thinning to UMN involvement, bulbar/limb onset, the total ALS functional rating scale (ALSFRS-R), and its bulbar and upper limb subscore. In total, 93 ALS… CONTINUE READING