Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways.

@article{Lu2011FocalPL,
  title={Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways.},
  author={Jie Lu and Hesheng Liu and Miao Zhang and Danhong Wang and Yanxiang Cao and Qingfeng Ma and Dongdong Rong and Xiaoyi Wang and Randy L. Buckner and Kuncheng Li},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 42},
  pages={15065-71}
}
Intrinsic functional connectivity detected by functional MRI (fMRI) provides a useful but indirect approach to study the organization of human brain systems. An unresolved question is whether functional connectivity measured by resting-state fMRI reflects anatomical connections. In this study, we used the well-characterized anatomy of cerebrocerebellar circuits to directly test whether intrinsic functional connectivity is associated with an anatomic pathway. Eleven first-episode stroke patients… CONTINUE READING
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