Focal photothrombotic lesion of the rat motor cortex increases BDNF levels in motor-sensory cortical areas not accompanied by recovery of forelimb motor skills.

@article{Sulejczak2007FocalPL,
  title={Focal photothrombotic lesion of the rat motor cortex increases BDNF levels in motor-sensory cortical areas not accompanied by recovery of forelimb motor skills.},
  author={Dorota Sulejczak and Ewelina Ziemlińska and Julita Czarkowska-Bauch and Ewa Nosecka and Ryszard Strzalkowski and Małgorzata Skup},
  journal={Journal of neurotrauma},
  year={2007},
  volume={24 8},
  pages={1362-77}
}
Brain infarct triggers neurodegeneration that often shades spontaneous plasticity, occurring in the areas related anatomically and functionally to the infarcted structures. Neurotrophins which promote neuronal survival and plasticity, may protect neurons and enhance remodeling of the remaining circuits, leading to restoration of function. In particular, the crucial role of brain-derived neurotrophic factor (BDNF) in cortical function is well documented. Since BDNF was implicated in the… CONTINUE READING
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