Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory.

@article{Bartsch2010FocalLO,
  title={Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory.},
  author={Thorsten Bartsch and Robby Sch{\"o}nfeld and Franz Josef Mueller and Karsten Alfke and Bernd Leplow and Josef Bernd Aldenhoff and Guenther Deuschl and J-M. Koch},
  journal={Science},
  year={2010},
  volume={328 5984},
  pages={1412-5}
}
A critical role in place learning has been attributed to place cells within the cornu ammonis 1 (CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human hippocampus with regard to place learning remains elusive. Using a virtual Morris water maze, we investigated patients with acute transient global amnesia (TGA), a rare self-limiting dysfunction of the hippocampal system. Fourteen individuals with selective and focal lesions in the CA1 sector of the hippocampus showed a… CONTINUE READING

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