Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice.

Abstract

In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.

Extracted Key Phrases

4 Figures and Tables

0200400'02'04'06'08'10'12'14'16
Citations per Year

2,284 Citations

Semantic Scholar estimates that this publication has 2,284 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Stagliano1999FocalIP, title={Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice.}, author={N. E. Stagliano and Miguel A. P{\'e}rez-Pinz{\'o}n and Michael A. Moskowitz and Philip Lin Huang}, journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year={1999}, volume={19 7}, pages={757-61} }