Focal ischemia enhances the adverse effect potential of N-methyl-D-aspartate receptor antagonists in rats.

Abstract

Recent clinical trials with non-competitive and competitive N-methyl-D-aspartate (NMDA) receptor antagonists in patients with stroke have shown that these patients develop more adverse effects, particularly psychomimetic effects such as hallucinations and agitation, than normal volunteers at equivalent doses. We therefore examined whether such increased… (More)

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@article{Loescher1998FocalIE, title={Focal ischemia enhances the adverse effect potential of N-methyl-D-aspartate receptor antagonists in rats.}, author={Wayne H. Loescher and Pawel Wlaz and Lorand Szabo}, journal={Neuroscience letters}, year={1998}, volume={240 1}, pages={33-6} }