Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.

@article{Alvarez2015FocalDI,
  title={Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.},
  author={Jorge Iv{\'a}n Alvarez and Olivia Saint-Laurent and Alisha Godschalk and Simone Terouz and Casper Briels and Sandra Larouche and Lyne Bourbonni{\`e}re and Catherine Larochelle and Alexandre Prat},
  journal={Neurobiology of disease},
  year={2015},
  volume={74},
  pages={14-24}
}
Early changes in the normal appearing white matter of multiple sclerosis (MS) patients precede the appearance of gadolinium-enhancing lesions. Although these findings suggest blood-brain barrier (BBB) breakdown as an important feature in MS pathogenesis, limited information is available on the BBB alterations during lesion genesis. Here, we perform a longitudinal characterization of the vascular, neuropathological and immunological changes before lesion formation in mice developing spontaneous… CONTINUE READING