Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics.

@article{Morrison1999FocalDD,
  title={Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics.},
  author={Paul F. Morrison and Michael Y. Chen and Richard S. Chadwick and Russell R. Lonser and Edward H. Oldfield},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4 Pt 2},
  pages={R1218-29}
}
Direct interstitial infusion is a technique capable of delivering agents over both small and large dimensions of brain tissue. However, at a sufficiently high volumetric inflow rate, backflow along the catheter shaft may occur and compromise delivery. A scaling relationship for the finite backflow distance along this catheter in pure gray matter ( x m) has been determined from a mathematical model based on Stokes flow, Darcy flow in porous media, and elastic deformation of the brain tissue: x m… CONTINUE READING