Focal cerebral perfusion defects demonstrated by 99mTc-hexamethylpropyleneamine oxime SPECT in elderly depressed patients.

@article{Vasile1996FocalCP,
  title={Focal cerebral perfusion defects demonstrated by 99mTc-hexamethylpropyleneamine oxime SPECT in elderly depressed patients.},
  author={Russell G. Vasile and Richard B. Schwartz and Basem Garada and B. leonard Holman and Murray Alpert and Patrick Davidson and Joseph J. Schildkraut},
  journal={Psychiatry research},
  year={1996},
  volume={67 1},
  pages={59-70}
}
High resolution single photon emission computed tomography (SPECT) was used to evaluate regional cerebral blood flow (rCBF) in 14 acutely depressed elderly patients and 29 normal subjects. SPECT images of the two groups were randomized and blindly read. Foci of decreased radionuclide uptake were assessed by number and location. The total number of rCBF defects per whole brain study was significantly greater in the depressed patients than in the normal subjects. A significantly greater number of… CONTINUE READING