Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala.

@article{Wong1995FocalCI,
  title={Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala.},
  author={M L Wong and Sarah A. Loddick and Peter B. Bongiorno and Philip W. Gold and Nancy J. Rothwell and Julio Licinio},
  journal={Neuroreport},
  year={1995},
  volume={6 13},
  pages={1785-8}
}
Corticotropin-releasing hormone (CRH) antagonism has neuroprotective effects in models of ischemia. We examined CRH mRNA by in situ hybridization in a well-established rat model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion (MCAo). In ischemic cortex CRH mRNA levels were elevated 2.6-fold 60 min after MCAo, compared with sham operated animals. CRH mRNA was also induced in the amygdala, 60 min following ischemia, in a pattern which was qualitatively different… CONTINUE READING

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