Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin aminonucleoside.

@article{Diamond1986FocalAS,
  title={Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin aminonucleoside.},
  author={Jennifer R Diamond and Morris J. Karnovsky},
  journal={The American journal of pathology},
  year={1986},
  volume={122 3},
  pages={481-7}
}
Focal and segmental glomerulosclerosis (FSGS) represents a final pathologic pattern of a number of human renal disorders. Among laboratory models, repeated intraperitoneal injections of the aminonucleoside of puromycin (PA) produces a histologic pattern not unlike the human process. A single intravenous dose of this drug usually results in glomerular morphologic changes in rats resembling those in human nephrotic syndrome with minimal changes. This report describes acute and chronic glomerular… CONTINUE READING