Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat

@article{Sechi2003FocalAS,
  title={Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat},
  author={GianPietro Sechi and Pier Luigi De Riu and Ombretta Mameli and Giovanni Andrea Deiana and Giovanni Antonio Cocco and Giulio Rosati},
  journal={Seizure},
  year={2003},
  volume={12},
  pages={508-515}
}
The objective of this study was to document the convulsant properties of thiocolchicoside in rats, and to characterise the electroclinical pattern of epileptic seizures. Experiments were carried out in three groups of male Wistar rats: in group A, thiocolchicoside was applied topically to the pia, or given by microinjection to the cerebral cortex (2 microg/microl); in group B, the drug was administered parenterally (6 mg/kg) to rats with minimal lesions of the dura and arachnoid membranes; in… 
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Disruption of Normal Cytoskeletal Dynamics May Play a Key Role in the Pathogenesis of Epilepsy
  • J. Gardiner, J. Marc
  • Biology, Medicine
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2010
TLDR
A number of mutations in both microtubule-associated proteins (MAPs) and actin-binding proteins, as well as altered expression levels of several cytoskeletal proteins, are known to be involved in epilepsy and are likely to contribute to the pathogenesis of epilepsy through mechanisms such as increased neurotrophic support to neurons and increased sprouting of mossy fibers.
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