Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model.

@article{Raay2012FocalAO,
  title={Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model.},
  author={Leena van Raay and Valentina Jovanovska and Margaret Morris and Terence J. O'Brien},
  journal={Epilepsia},
  year={2012},
  volume={53 3},
  pages={477-84}
}
PURPOSE Neuropeptide Y (NPY) is an inhibitory neurotransmitter that suppresses focal and generalized seizures in animal models. In this study, we investigated the sites within the thalamocortical circuit that NPY acts to suppress seizures in genetic absence epilepsy rats from Strasbourg (GAERS). METHODS In conscious freely moving GAERS, NPY was administered via intracerebral microcannulae implanted bilaterally into one of the following regions: primary somatosensory cortex (S1), secondary… CONTINUE READING

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