Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

@inproceedings{Goffin2006FocalAS,
  title={Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers},
  author={J{\'e}r{\^o}me M. Goffin and Philippe Pittet and Gabor Csucs and Jost Wendelin Lussi and Jean-Jacques Meister and Boris Hinz},
  booktitle={The Journal of cell biology},
  year={2006}
}
Expression of alpha-smooth muscle actin (alpha-SMA) renders fibroblasts highly contractile and hallmarks myofibroblast differentiation. We identify alpha-SMA as a mechanosensitive protein that is recruited to stress fibers under high tension. Generation of this threshold tension requires the anchoring of stress fibers at sites of 8-30-microm-long "supermature" focal adhesions (suFAs), which exert a stress approximately fourfold higher (approximately 12 nN/microm2) on micropatterned deformable… CONTINUE READING

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