Focal adhesion sites and the removal of substratum-bound fibronectin

@article{Grinnell1986FocalAS,
  title={Focal adhesion sites and the removal of substratum-bound fibronectin},
  author={Frederick Grinnell},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={2697 - 2706}
}
Fibronectin was not removed from the substratum beneath focal adhesion sites when fibroblasts spread in serum-free medium on adsorbed fibronectin substrata, or when fibroblasts spread in serum-containing medium on covalently cross-linked fibronectin substrata. Under these conditions, there was colocalization between 140-kD fibronectin receptors and focal adhesion sites. It was concluded that removal of adsorbed fibronectin from beneath focal adhesion sites was a mechanical process that required… CONTINUE READING

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The effect of serum was nonspecific since serum could be replaced by equivalent concentrations of serum albumin , ovalbumin , or gamma globulins .
The effect of serum was nonspecific since serum could be replaced by equivalent concentrations of serum albumin , ovalbumin , or gamma globulins .
The effect of serum was nonspecific since serum could be replaced by equivalent concentrations of serum albumin , ovalbumin , or gamma globulins .
The effect of serum was nonspecific since serum could be replaced by equivalent concentrations of serum albumin , ovalbumin , or gamma globulins .
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