Focal adhesion motility revealed in stationary fibroblasts.

@article{Smilenov1999FocalAM,
  title={Focal adhesion motility revealed in stationary fibroblasts.},
  author={Lubomir B. Smilenov and Andrey Mikhailov and Robert J. Pelham and Eugene E. Marcantonio and Gregg G. Gundersen},
  journal={Science},
  year={1999},
  volume={286 5442},
  pages={1172-4}
}
Focal adhesions (FAs) are clustered integrins and associated proteins that mediate cell adhesion and signaling. A green fluorescent protein-beta1 integrin chimera was used to label FAs in living cells. In stationary cells, FAs were highly motile, moving linearly for several plaque lengths toward the cell center. FA motility was independent of cell density and resulted from contraction of associated actin fibers. In migrating cells, FAs were stationary and only moved in the tail. FA motility in… CONTINUE READING
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