Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.

@article{Playford2008FocalAK,
  title={Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.},
  author={Martin P. Playford and Kavita Vadali and Xinming Cai and Keith Burridge and Michael D Schaller},
  journal={Experimental cell research},
  year={2008},
  volume={314 17},
  pages={3187-97}
}
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase that plays a key role in cellular processes such as cell adhesion, migration, proliferation and survival. Recent studies have also implicated FAK in the regulation of cell-cell adhesion. Here, evidence is presented showing that siRNA-mediated suppression of FAK levels in NBT-II cells and expression of dominant negative mutants of FAK caused loss of epithelial cell morphology and inhibited the formation of cell-cell adhesions. Rac and… CONTINUE READING

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