Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways.

@article{Huang2007FocalAK,
  title={Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways.},
  author={Danshan Huang and Michelle Khoe and Merone Befekadu and Sue Y Chung and Yasunori Takata and Dusko Ilic and Michael Bryer-Ash},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={292 4},
  pages={
          C1339-52
        }
}
Focal adhesion kinase (FAK) is important to cellular functions such as proliferation, migration, and survival of anchorage-dependent cells. We investigated the role of FAK in modulating normal cellular responses, specifically cell survival in response to inflammatory stimuli and serum withdrawal, using FAK-knockout (FAK(-/-)) embryonic fibroblasts. FAK(-/-) fibroblasts were more vulnerable to TNF-alpha-induced apoptosis, as measured by terminal deoxynucleotidyl transferase positivity. FAK… CONTINUE READING