Focal adhesion kinase is required for KSHV vGPCR signaling.

  title={Focal adhesion kinase is required for KSHV vGPCR signaling.},
  author={Meilan He and Thomas Bakken and Alia Kassimova and Chris Boshoff and Nicola Philpott and Mark L. Cannon},
  journal={Molecular carcinogenesis},
  volume={51 4},
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, an angiogenic and inflammatory endothelial cell (EC) tumor that is common in areas of high KSHV prevalence. KSHV encodes a pro-angiogenic viral chemokine receptor (vGPCR) that promotes EC growth in vitro and KS-like tumors in mouse models. vGPCR is therefore… CONTINUE READING