Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts.

@article{Young2009FocalAK,
  title={Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts.},
  author={Suzanne R. L. Young and Rita L Gerard-O'Riley and J J Kim and Fredrick M. Pavalko},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 3},
  pages={411-24}
}
Mechanical loading of bone is important for maintenance of bone mass and structural stability of the skeleton. When bone is mechanically loaded, movement of fluid within the spaces surrounding bone cells generates fluid shear stress (FSS) that stimulates osteoblasts, resulting in enhanced anabolic activity. The mechanisms by which osteoblasts convert the external stimulation of FSS into biochemical changes, a process known as mechanotransduction, remain poorly understood. Focal adhesions are… CONTINUE READING

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