Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.

@article{Quach2006FocalAK,
  title={Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.},
  author={Navaline L. Quach and Thomas A Rando},
  journal={Developmental biology},
  year={2006},
  volume={293 1},
  pages={
          38-52
        }
}
A central question in muscle biology is how costameres are formed and become aligned with underlying myofibrils in mature tissues. Costameres are composed of focal adhesion proteins, including vinculin and paxillin, and anchor myofibril Z-bands to the sarcolemma. In the present study, we investigated the process of costamere formation ("costamerogenesis") in differentiating primary mouse myoblasts. Using vinculin and paxillin as costameric markers, we found that two additional focal adhesion… CONTINUE READING
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