Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype.

@article{Durieux2009FocalAK,
  title={Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype.},
  author={Anne-C{\'e}cile Durieux and Giuseppe D'Antona and Dominique Desplanches and Damien Freyssenet and Stephan Klossner and Roberto Bottinelli and Martin Fl{\"u}ck},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 14},
  pages={
          3703-17
        }
}
Striated muscle exhibits a pronounced structural-functional plasticity in response to chronic alterations in loading. We assessed the implication of focal adhesion kinase (FAK) signalling in mechano-regulated differentiation of slow-oxidative muscle. Load-dependent consequences of FAK signal modulation were identified using a multi-level approach after electrotransfer of rat soleus muscle with FAK-expression plasmid vs. empty plasmid-transfected contralateral controls. Muscle fibre-targeted… CONTINUE READING

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