Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions.

Abstract

BACKGROUND INFORMATION FAK (focal adhesion kinase), an essential non-receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signalling and mechanotransduction. FAK-dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion. Whereas roles… (More)
DOI: 10.1042/BC20090104

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