Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

@article{Brunton2007FocalAK,
  title={Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex},
  author={Valerie G Brunton and Mark Holt and Gordon W. McLean and Christopher H. Gray and Gareth E Jones and Margaret C Frame},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1046-1056}
}
Networks of actin filaments, controlled by the Arp2/3 complex, drive membrane protrusion during cell migration. How integrins signal to the Arp2/3 complex is not well understood. Here, we show that focal adhesion kinase (FAK) and the Arp2/3 complex associate and colocalize at transient structures formed early after adhesion. Nascent lamellipodia, which originate at these structures, do not form in FAK-deficient cells, or in cells in which FAK mutants cannot be autophosphorylated after integrin… CONTINUE READING
Highly Cited
This paper has 121 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

121 Citations

051015'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 121 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Structural basis for the autoinhibition of focal adhesion kinase

  • D Lietha
  • Cell 129,
  • 2007