Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.

@article{Hamamura2008FocalAK,
  title={Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.},
  author={Kazunori Hamamura and Momoko Tsuji and Yuki Ohkawa and Hideyuki Nakashima and Sayaka Miyazaki and Takeshi Urano and Noriyuki Yamamoto and Minoru Ueda and Koichi Furukawa},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1780 3},
  pages={
          513-9
        }
}
Mass spectrometry analysis of immunoprecipitates from serum-treated GD3-expressing melanoma cells with PY20 (anti-phosphotyrosine antibody) revealed that focal adhesion kinase (FAK) is more strongly activated in GD3-expressing cells than in GD3-negative cells. Involvement of FAK in the increased proliferation and invasion in GD3-expressing melanomas was demonstrated by siRNA-mediated knockdown. Also, it was shown that FAK is located up-stream of p130Cas and paxillin in the enhanced signaling… CONTINUE READING
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