Focal adhesion kinase as a regulator of cell tension in the progression of cancer.

@article{Tilghman2008FocalAK,
  title={Focal adhesion kinase as a regulator of cell tension in the progression of cancer.},
  author={Robert W. Tilghman and John T. Parsons},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 1},
  pages={45-52}
}
Growing evidence indicates that critical steps in cancer progression such as cell adhesion, migration, and cell cycle progression are regulated by the composition and organization of the microenvironment. The adhesion of cancer cells to components of the microenvironment and the forces transmitted to the cells via the actinomyosin network and the signaling complexes organized within focal adhesions allow cancer cells to sense the local topography of the extracellular matrix and respond… CONTINUE READING

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