Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.

@article{Zhao2011FocalAK,
  title={Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.},
  author={Xiaofeng Zhao and Jun-Lin Guan},
  journal={Advanced drug delivery reviews},
  year={2011},
  volume={63 8},
  pages={610-5}
}
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in integrin-mediated signal transductions and also participates in signaling by other cell surface receptors. In integrin-mediated cell adhesion, FAK is activated via disruption of an auto-inhibitory intra-molecular interaction between its amino terminal FERM domain and the central kinase domain. The activated FAK forms a complex with Src family kinases, which initiates multiple downstream signaling pathways… CONTINUE READING

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