Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.

@article{Lie2012FocalAK,
  title={Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.},
  author={Pearl P. Y. Lie and Dolores D. Mruk and Ka Wai Mok and Linlin Su and W. M. Peter Lee and C. Yan Cheng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 31},
  pages={12562-7}
}
Focal adhesion kinase (FAK), a nonreceptor protein tyrosine kinase, displays phosphorylation-dependent localization in the seminiferous epithelium of adult rat testes. FAK is an integrated component of the blood-testis barrier (BTB) involved in regulating Sertoli cell adhesion via its effects on the occludin-zonula occludens-1 complex. Herein, we report that p-FAK-Tyr(407) and p-FAK-Tyr(397) display restricted spatiotemporal and almost mutually exclusive localization in the epithelium… CONTINUE READING
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