Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.

@article{Tanwar2010FocalMD,
  title={Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.},
  author={Pradeep S Tanwar and Lihua Zhang and Yoshihiro Tanaka and Makoto Mark Taketo and Patricia K Donahoe and Jose M Teixeira},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 37},
  pages={16142-7}
}
Müllerian-inhibiting substance (MIS), which is produced by fetal Sertoli cells shortly after commitment of the bipotential gonads to testicular differentiation, causes Müllerian duct (MD) regression. In the fetal female gonads, MIS is not expressed and the MDs will differentiate into the internal female reproductive tract. We have investigated whether dysregulated β-catenin activity affects MD regression by expressing a constitutively activated nuclear form of β-catenin in the MD mesenchyme. We… CONTINUE READING

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