Focal Inflammation Causes Carbenoxolone-Sensitive Tactile Hypersensitivity in Mice.

Abstract

A focal and transitory inflammation induced by injection of complete Freund's adjuvant (CFA) in the submandibular skin of mice elicits pain behavior that persists for several weeks after the initial inflammation has resolved. Chronic pain, assessed as tactile hypersensitivity to stimulation with von Frey filaments, was evident from 1-7 weeks following CFA… (More)

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