Focal Adhesion Kinase Is a Key Mediator of Human Trophoblast Development

@article{Macphee2001FocalAK,
  title={Focal Adhesion Kinase Is a Key Mediator of Human Trophoblast Development},
  author={Daniel J Macphee and Homa Mostachfi and Robin Han and Stephen James Lye and Martin Post and Isabella Caniggia},
  journal={Laboratory Investigation},
  year={2001},
  volume={81},
  pages={1469-1483}
}
Trophoblast differentiation during the first trimester of pregnancy involves cell proliferation and invasion and extracellular matrix (ECM) remodeling. Reports have indicated that, in a variety of cell types, processes such as proliferation, invasion, and ECM remodeling require the turnover of focal adhesions mediated by a cytoplasmic tyrosine kinase named focal adhesion kinase (FAK). Therefore, in the present study we examined the expression and spatial localization of FAK during early human… CONTINUE READING