Foamy virus vector integration sites in normal human cells.

  title={Foamy virus vector integration sites in normal human cells.},
  author={Grant Trobridge and Daniel G. Miller and M. A. Jacobs and James M. Allen and Hans-Peter Kiem and Rajinder K Kaul and David W. Russell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 5},
Foamy viruses (FVs) or spumaviruses are retroviruses that have been developed as vectors, but their integration patterns have not been described. We have performed a large-scale analysis of FV integration sites in unselected human fibroblasts (n = 1,008) and human CD34(+) hematopoietic cells (n = 1,821) by using a bacterial shuttle vector and a comparable analysis of lentiviral vector integration sites in CD34(+) cells (n = 1,331). FV vectors had a distinct integration profile relative to other… CONTINUE READING


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