Foamy virus integration.

  title={Foamy virus integration.},
  author={Thomas Juretzek and Teresa Holm and Kathleen G{\"a}rtner and Sylvia Kanzler and Dirk Lindemann and Ottmar Herchenr{\"o}der and Marcus Picard-Maureau and Matthias Rammling and Martin Heinkelein and Axel Rethwilm},
  journal={Journal of virology},
  volume={78 5},
It had been suggested that during integration of spumaretroviruses (foamy viruses) the right (U5) end of the cDNA is processed, while the left (U3) remains uncleaved. We confirmed this hypothesis by sequencing two-long terminal repeat (LTR) circle junctions of unintegrated DNA. Based on an infectious foamy virus molecular clone, a set of constructs harboring mutations at the 5' end of the U3 region in the 3' LTR was analyzed for particle export, reverse transcription, and replication. Following… CONTINUE READING


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