Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells.

  title={Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells.},
  author={Mahboobeh Forouzanfar and Farzaneh Rabiee and Kamran Ghaedi and Siamak Beheshti and Somayeh Tanhaei and Alireza Shoaraye Nejati and Mohammad Jodeiri Farshbaf and Hossein Baharvand and Mohammad Hossein Nasr-esfahani},
  journal={Cell biology international},
  volume={39 5},
Fndc5 has been recently recognized as a myokine which could be cleaved and secreted into blood stream. It is termed as irisin with an important role in thermogenesis and energy homeostasis. Increased expression of Fndc5 has been reported upon retinoic acid treatment during neural differentiation and its knockdown decreased neural differentiation and neurite outgrowth. This study tries to evaluate the effect of Fndc5 overexpression on rate of neural differentiation in mouse. (Thus, transduced… CONTINUE READING


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