Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice

@article{Xiong2019Fndc5LA,
  title={Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice},
  author={Yan Xiong and Zihuan Wu and Bin Zhang and Chao Wang and Fengyi Mao and Xiao Liu and Ke-ping Hu and Xiaobo Sun and Wen Jin and Shihuan Kuang},
  journal={The FASEB Journal},
  year={2019},
  volume={33},
  pages={5876 - 5886}
}
Fibronectin type III domain containing 5 (Fndc5) is a transmembrane protein highly expressed in the skeletal muscle. It was reported that exercise promotes the shedding of the extracellular domain of Fndc5, generating a circulating peptide (irisin) that cross‐talks to adipose tissues to convert lipid‐storing white adipocytes to energy‐catabolizing beige adipocytes. However, the requirement of Fndc5 in mediating the beneficial effect of exercise remains to be determined. Here, we created a mouse… Expand
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