Flying vaccinator; a transgenic mosquito delivers a Leishmania vaccine via blood feeding.

@article{Yamamoto2010FlyingVA,
  title={Flying vaccinator; a transgenic mosquito delivers a Leishmania vaccine via blood feeding.},
  author={Daisuke S Yamamoto and Hiroshi Nagumo and Shigeto Yoshida},
  journal={Insect molecular biology},
  year={2010},
  volume={19 3},
  pages={
          391-8
        }
}
'Flying vaccinator' is the concept of using genetically engineered hematophagous insects to deliver vaccines. Here we show the generation of a transgenic anopheline mosquito that expresses the Leishmania vaccine candidate, SP15, fused to monomeric red fluorescent protein (mDsRed) in its salivary glands. Importantly, mice bitten repeatedly by the transgenic mosquitoes raised anti-SP15 antibodies, indicating delivery of SP15 via blood feeding with its immunogenicity intact. Thus, this technology… CONTINUE READING
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