Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins

@article{Shepherd1984FlyAF,
  title={Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins},
  author={John C. W. Shepherd and William J. McGinnis and Andr{\'e}s E. Carrasco and Eddy M. De Robertis and W. J. Gehring},
  journal={Nature},
  year={1984},
  volume={310},
  pages={70-71}
}
Homoeotic genes in the bithorax and Antennapedia complexes of Drosophila melanogaster appear to specify the developmental fate of segments of the fly. Some of these genes (Ultrabithorax, Antennapedia and fushi tarazu) share homology due to their conservation of a ‘homoeo domain’1,2 consisting of 60 amino acids. Cross-hybridization and cloning experiments show that the homoeo domain is conserved in a frog (Xenopus laevis) gene expressed in early development3 and may also be present in earthworm… CONTINUE READING

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