Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network

Abstract

Constraint-based flux analysis of metabolic network model quantifies the reaction flux distribution to characterize the state of cellular metabolism. However, metabolites are key players in the metabolic network and the current reaction-centric approach may not account for the effect of metabolite perturbation on the cellular physiology due to the inherent… (More)
DOI: 10.1186/1752-0509-3-117

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