Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p.

@article{Ott2005FluxOS,
  title={Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p.},
  author={Rene G. Ott and Karin Athenstaedt and Claudia Hrastnik and E. von Leitner and Helmut Bergler and Guenther Daum},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1735 2},
  pages={111-8}
}
Lanosterol C-14 demethylase Erg11p of the yeast Saccharomyces cerevisiae catalyzes the enzymatic step following formation of lanosterol by the lanosterol synthase Erg7p in lipid particles (LP). Localization experiments employing microscopic inspection and cell fractionation revealed that Erg11p in contrast to Erg7p is associated with the endoplasmic reticulum (ER). An erg11Delta mutation in erg3Delta background, which is required to circumvent lethality of the erg11 defect, did not only change… CONTINUE READING

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