Flux of morphine, fentanyl, and alfentanil through rabbit arteries in vivo. Evidence supporting a vascular route for redistribution of opioids between the epidural space and the spinal cord.

Abstract

BACKGROUND It has been suggested that opioids may move from the epidural space to the spinal cord by way of the spinal radicular arteries. However, there are no data that address this proposed mechanism. The goal of the current study was to determine whether the radicular arterial supply of the spinal cord is a viable route for movement of opioids between… (More)

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