Flux of ionic dyes across microneedle-treated skin: effect of molecular characteristics.

@article{Gomaa2012FluxOI,
  title={Flux of ionic dyes across microneedle-treated skin: effect of molecular characteristics.},
  author={Yasmine A. Gomaa and Martin James Garland and Fiona J. McInnes and Ryan F Donnelly and Labiba Khalil El-Khordagui and Clive G. Wilson},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={438 1-2},
  pages={140-9}
}
Drug flux across microneedle (MN)-treated skin is influenced by the characteristics of the MN array, formed microconduits and physicochemical properties of the drug molecules in addition to the overall diffusional resistance of microconduits and viable tissue. Relative implication of these factors has not been fully explored. In the present study, the in vitro permeation of a series of six structurally related ionic xanthene dyes with different molecular weights (MW) and chemical substituents… CONTINUE READING