Flux balance analysis of biological systems: applications and challenges

@article{Raman2009FluxBA,
  title={Flux balance analysis of biological systems: applications and challenges},
  author={Karthik Raman and Nagasuma R. Chandra},
  journal={Briefings in bioinformatics},
  year={2009},
  volume={10 4},
  pages={
          435-49
        }
}
Systems level modelling and simulations of biological processes are proving to be invaluable in obtaining a quantitative and dynamic perspective of various aspects of cellular function. In particular, constraint-based analyses of metabolic networks have gained considerable popularity for simulating cellular metabolism, of which flux balance analysis (FBA), is most widely used. Unlike mechanistic simulations that depend on accurate kinetic data, which are scarcely available, FBA is based on the… 

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