Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.

@article{Yao2001FluvoxaminetheophyllineIG,
  title={Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.},
  author={Caiping Yao and Kent L. Kunze and Evan D. Kharasch and Yinghong Wang and William F Trager and Isabelle Ragueneau and Ren{\'e} H. Levy},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={70 5},
  pages={415-24}
}
OBJECTIVE Several reports indicate that fluvoxamine decreases the clearance of cytochrome P4501A2 (CYP1A2) substrates. This study compared in vitro and in vivo inhibition potencies of fluvoxamine toward CYP1A2 with an approach based on inhibition constants (K(i)) determined in vitro and in vivo. METHODS In vitro inhibition constant values were determined… CONTINUE READING