Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.

  title={Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.},
  author={Kerry E Culm-Merdek and Lisa L. von Moltke and Jerold S. Harmatz and David J Greenblatt},
  journal={British journal of clinical pharmacology},
  volume={60 5},
BACKGROUND Coadministration of fluvoxamine impairs the clearance of caffeine and prolongs its elimination half-life, which is attributable to inhibition of CYP1A2 by fluvoxamine. The clinical importance of this interaction is not established. AIM To evaluate the effects of fluvoxamine on the kinetics and dynamics of single doses of caffeine. METHODS Seven healthy subjects received single 250 mg doses of caffeine (or matching placebo) together with fluvoxamine (four doses of 100 mg over 2… CONTINUE READING
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